Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Vyvanse is available as a fast-acting or slow-release tablet or chewable. The drug takes effect within about 2 hours of use and typically lasts 10-12 hours following the dose. It’s also normally prescribed in 10, 20, or 30mg pills or chewable tablets. This avoids many of the issues with Adderall, where users who can’t take pills are told to break the capsules open.  

More than 10 million Americans are prescribed Vyvanse or its equivalents. Prescriptions are offered for ADHD, in combination with antidepressants, and for binge eating disorder. Here, Vyvanse is shown to be highly effective at helping individuals with ADHD. ADHD patients who take the grade show marked grade performance, work performance, self-esteem improvements, and reduction in self-harm and suicide attempts. While Vyvanse performs similarly to Adderall, it’s more and more preferred in medical settings because of duration of action. Vyvanse typically lasts 12 hours, or more than enough time for the average school or workday. Adderall typically lasts 6 and must be taken twice throughout the day.  

All amphetamines can be used as a physical and mental performance enhancer. Vyvanse is rarely used for performance enhancement (although it does happen). Instead, the drug is favored as a “study” drug. Here, students in high school and college use Vyvanse to increase focus, memory, working memory, and inhibition control. This makes it easier for students to study, to stay awake and alert for tests. Some studies suggest that as many as 35% of college students use amphetamine derivatives like Vyvanse for this purpose. At the same time, taking larger doses can result in cognitive deterioration rather than modest improvement. Here, users take anywhere from 20 to 50 mg of Vyvanse, usually spread out over the duration of their study.  

All amphetamines cause euphoria in large enough doses. Here, the user will experience 10-12 hours of being “high”, where they seem energetic, active, engaged, and quick to focus on something. This euphoria is normally followed by a crash period, especially if the individual is taking high doses of the drug. However, Vyvanse is not popular for euphoric purposes because it cannot be injected. The drug only works orally, limiting the total high the user can get from the drug.  

Vyvanse is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Shire PLC. Vyvanse is a central nervous system stimulant medication used to treat ADHD symptoms in children (Attention Deficit Hyperactivity Disorder) and moderate to severe binge eating disorder (BED) in adults.

Vyvanse is not recommended for weight loss. The use of other sympathomimetic drugs for weight loss has been associated with serious cardiovascular adverse events. The safety and effectiveness of Vyvanse for the treatment of obesity have also not been established.

• Vyvanse 10 mg
• Vyvanse 20 mg
• Vyvanse 30 mg
• Vyvanse 40 mg
• Vyvanse 50 mg
• Vyvanse 60 mg
• Vyvanse 70 mg.

Take Vyvanse once a day in the morning. It’s best to take it in the morning because it can interfere with sleep if taken later in the day. Vyvanse can be taken with or without food. Vyvanse is often started at a lower dose and increased based on your response. Always be sure to take Vyvanse exactly as your doctor tells you to take it.

Your doctor may sometimes stop your Vyvanse treatment for a period of time to check your symptoms of ADHD or binge eating disorder.

Vyvanse comes in capsules or chewable tablets. For children or others who prefer a softer or liquid formulation, the Vyvanse capsules can be opened and taken with yogurt, water or orange juice. Ask your pharmacist how to do this correctly.

Don’t take Vyvanse if you or your child are taking or have taken an anti-depression medicine called a monoamine oxidase inhibitor (MAOI) within the past 14 days. Also, don’t take Vyvanse if you are sensitive or allergic to Vyvanse or any of its ingredients, or had a reaction to other stimulant medicines.

•  adults with ADHD, Vyvanse was shown in clinical studies to improve attention at 2 hours and up to 14 hours after taking a dose.
• In children with ADHD, aged 6-12, Vyvanse was shown to start working within 1.5 hours after taking the medication and up to 13 hours after the morning dose.
• Vyvanse is a maintenance (long-term) medication taken once a day in the morning, but your doctor may hold your treatment for a period of time to check your symptoms.
• Common side effects with Vyvanse often include decreased appetite, trouble sleeping, decreased weight and dry mouth. Let your doctor know if you have high blood pressure.

Vyvanse is similar to Adderall. The main difference is that Adderall is a mixture of four different kinds of amphetamine salts (one of which is dextroamphetamine) while Vyvanse only contains one type of amphetamine salt, called lisdexamfetamine.

Vyvanse is a prodrug, meaning lisdexamfetamine is converted into dexamphetamine once it is in the body. An advantage of Vyvanse is that it may be less likely to abuse. Vyvanse is a federally controlled substance because it has a high potential for drug abuse and can lead to dependence. You should store Vyvanse at room temperature, but away from light and moisture. Do not store in the bathroom, and keep all medications away from children and pets.

Vyvanse belongs to a class of drugs known as amphetamines. These work by blocking the reuptake of norepinephrine and dopamine into the presynaptic neuron and increasing the release of these monoamines into the extraneuronal space.

There may be an interaction between Vyvanse (Lisdexamfetamine) and any of the following:

• Abiraterone
• Acetazolamide
• Aliskiren
• alpha-agonists (e.g., Clonidine, methyldopa)
• Amiodarone
• angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
• angiotensin receptor blockers (ARBs; e.g., Candesartan, Irbesartan, Losartan)
• antacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• ascorbic acid (vitamin C)
• Atomoxetine
• beta-blockers (e.g., Atenolol, Propranolol)
• beta-2 agonists (e.g., salbutamol, salmeterol, terbutaline)
• Bromocriptine
• Bupropion
• Buspirone
• caffeine
• calcium channel blockers (e.g., Diltiazem, Nifedipine, Verapamil)
• cannabis
• Cyclobenzaprine
• decongestant cold medications (e.g., phenylephrine, Pseudoephedrine)
• decongestant eye drops and nose sprays (e.g., naphazoline, oxymetazoline, xylometazoline)
• Dextroamphetamine
• Dextromethorphan
• diuretics (water pills; e.g., Furosemide, Metolazone, Hydrochlorothiazide)
• Dorzolamide
• Dronedarone
• epinephrine
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• Ethosuximide
• imatinib
• isoniazid
• ketoconazole
• Linezolid
• lithium
• lopinavir
• Methadone
• methylene blue
• Methylphenidate
• Mirabegron
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., moclobemide, phenelzine, Rasagiline, Selegiline, tranylcypromine)
• multivitamins (with ADE)
• Nabilone
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• Nilotinib
• Phenobarbital
• Phenytoin
• quinidine
• quinine
• ritonavir
• St. John’s wort
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, Venlafaxine)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• sodium bicarbonate
• Tapentadol
• terbinafine
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• Ticlopidine
• tipranavir
• Topiramate
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Imipramine)
• “triptan” migraine medications (e.g., Rizatriptan, Sumatriptan)
• Tryptophan

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Vyvanse (Lisdexamfetamine). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

You should not use Vyvanse if you:

• Are allergic to the active ingredient lisdexamfetamine dimesylate
• Are allergic to any of the other ingredients in Vyvanse
• Are taking monoamine oxidase inhibitors (MAOI)
• Are pregnant or are planning to become pregnant – there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to ADHD medications during pregnancy

Talk to your doctor before using Vyvanse if you:

• Are taking any of the medications that could interact with Vyvanse
• Are breastfeeding or are planning to breastfeed – lisdexamfetamine can pass into breast milk and may cause side effects in the nursing baby
• Have depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions
• Have kidney disease
• Have coronary artery disease
• Have blood circulation problems in your hands or feet
• Have a drug or alcohol addiction
• Have a family history of heart disease, heart problems, or high blood pressure

This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.